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Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development
Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 18, Iss 2, p 407 (2017)
- Publication Year :
- 2017
-
Abstract
- Aberrant miRNA expression is well recognized as a cancer hallmark, nevertheless miRNA function and expression does not always correlate in patients tissues and cell lines studies. In addition to this issue, miRNA strand usage conduces to increased cell signaling pathways modulation diversifying cellular processes regulation. In cervical cancer, 20 miRNA families are involved in carcinogenesis induction and development to this moment. These families have 5p and 3p strands with different nucleotide (nt) chain sizes. In general, mature 5p strands are larger: two miRNAs of 24 nt, 24 miRNAs of 23 nt, 35 miRNAs of 22 nt and three miRNAs of 21 nt. On the other hand, the 3p strands lengths observed are: seven miRNAs of 23 nt, 50 miRNAs of 22 nt, six miRNAs of 21 nt and four miRNAs of 20 nt. Based on the analysis of the 20 miRNA families associated with cervical cancer, 67 3p strands and 65 5p strands are selected suggesting selectivity and specificity mechanisms regulating cell processes like proliferation, apoptosis, migration, invasion, metabolism and Warburg effect. The insight reviewed here could be used in the miRNA based therapy, diagnosis and prognosis approaches.
- Subjects :
- 0301 basic medicine
cervical cancer
Cell
Uterine Cervical Neoplasms
Review
Biology
medicine.disease_cause
strand 3p
Catalysis
strand 5p
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
miRNA families
microRNA
medicine
Gene silencing
Humans
Genes, Tumor Suppressor
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Genetics
Organic Chemistry
Cancer
General Medicine
Oncogenes
medicine.disease
Warburg effect
Computer Science Applications
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
Cell Transformation, Neoplastic
lcsh:Biology (General)
lcsh:QD1-999
Cell culture
Multigene Family
Cancer research
Female
RNA Interference
Carcinogenesis
Function (biology)
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 18
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....32e2f78b2b4252610c272efa66d7d39c