Back to Search
Start Over
The shift of an intestinal 'microbiome' to a 'pathobiome' governs the course and outcome of sepsis following surgical injury
- Publication Year :
- 2016
-
Abstract
- Sepsis following surgical injury remains a growing and worrisome problem following both emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic therapy have improved outcomes in the first 24 to 48 h, late onset sepsis is now the most common cause of death in modern intensive care units. This time shift may be, in part, a result of prolonged exposure of the host to the stressors of critical illness which, over time, erode the health promoting intestinal microbiota and allow for virulent pathogens to predominate. Colonizing pathogens can then subvert the immune system and contribute to the deterioration of the host response. Here, we posit that novel approaches integrating the molecular, ecological, and evolutionary dynamics of the evolving gut microbiome/pathobiome during critical illness are needed to understand and prevent the late onset sepsis that develops following prolonged critical illness.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Resuscitation
Critical Care and Intensive Care Medicine
Article
Sepsis
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Intensive care
Antibiotic therapy
Medicine
Humans
Elective surgery
Intensive care medicine
Intraoperative Complications
business.industry
Microbiota
030208 emergency & critical care medicine
medicine.disease
Surgical Injury
Prolonged exposure
Gastrointestinal Tract
Intensive Care Units
030104 developmental biology
Intestinal Microbiome
Emergency Medicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....32f78107c89aece39e7dd9341064b0d8