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Adjuvant single-fraction radiotherapy is safe and effective for intractable keloids

Authors :
Il Han Kim
Sung W. Ha
Hak Chang
Hong Gyun Wu
Changhoon Song
Source :
Journal of Radiation Research
Publication Year :
2014
Publisher :
Oxford University Press (OUP), 2014.

Abstract

The aim of this study was to assess the feasibility and efficacy of high-dose, single-fraction electron beam radiotherapy for therapy-resistant keloids. Before 2010, intractable keloids were treated at our institution with post-operative irradiation of 6-15 Gy in 3-5 fractionations. For convenience and cost effectiveness, we have changed our treatment protocol to high-dose single-fraction radiotherapy. A total of 12 patients with 16 keloid lesions were treated from January 2010 to January 2013 in our department. A 10-Gy dose of electron irradiation was given within 72 h of the surgical excision. The mean follow-up period was 20 months. Treatments were well tolerated, and there was no recurrence in any of the patients. Severe adverse effects were not observed. Surgical excision of the keloid, followed by immediate, single-fraction, high-dose radiotherapy, is both safe and effective in preventing recurrence of therapy-resistant keloids.

Details

ISSN :
13499157 and 04493060
Volume :
55
Database :
OpenAIRE
Journal :
Journal of Radiation Research
Accession number :
edsair.doi.dedup.....3318d62bf908974aa28357de469302e0
Full Text :
https://doi.org/10.1093/jrr/rru025