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Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis
- Source :
- Oxidative Medicine and Cellular Longevity, Vol 2015 (2015), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Mechanical ventilation (MV) may amplify the lung-specific inflammatory response in preinjured lungs by elevating cytokine release and augmenting damage to the alveolar integrity. In this study, we test the hypothesis that MV exerts different negative impacts on inflammatory response at different time points of postlung injury. Basic lung injury was induced by cecal ligation and puncture (CLP) surgery in rats. Physiological indexes including blood gases were monitored during MV and samples were assessed following each experiment. LowVT(tidal volume) MV caused a slight increase in cytokine release and tissue damage at day 1 and day 4 after sepsis induced lung injury, while cytokine release from the lungs in the two moderately ventilatedVTgroups was amplified. Interestingly, in the two groups where rats received lowVTMV, we found that infiltration of inflammatory cells was only profound at day 4 after CLP. Marked elevation of protein leakage indicated a compromise in alveolar integrity in rats that received moderateVTMV at day 4 following CLP, correlating with architectural damage to the alveoli. Our study indicates that preinjured lungs are more sensitive to mechanical MV at later phases of sepsis, and this situation may be a result of differing immune status.
- Subjects :
- Male
Aging
Pathology
medicine.medical_specialty
Article Subject
Neutrophils
medicine.medical_treatment
Lung injury
Biochemistry
Sepsis
Rats, Sprague-Dawley
medicine
Animals
lcsh:QH573-671
Interleukin 6
Lung
Tidal volume
Mechanical ventilation
biology
business.industry
Interleukin-6
lcsh:Cytology
Cell Biology
General Medicine
Lung Injury
respiratory system
medicine.disease
Respiration, Artificial
Rats
medicine.anatomical_structure
Cytokine
Immunology
biology.protein
business
Infiltration (medical)
Bronchoalveolar Lavage Fluid
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19420994 and 19420900
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....3333390a60ae92bff1a0bc36e6e53f32