Back to Search
Start Over
Do we have serological evidences that chilblain‐like lesions are related to SARS‐CoV ‐2? A review of the literature
- Source :
- Dermatologic Therapy
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Summary The outbreak of chilblain‐like lesions (CLL) coincidentally to the COVID‐19 pandemic is a topic of great concern. SARS‐CoV‐2 was initially hypothesized as the etiologic agent of CLL, but, since nasopharyngeal swabs seldom resulted positive, dermatologists’ attention focused on the search for specific SARS‐CoV‐2 antibodies. Many papers were published contemporarily on this topic, reporting limited case series. We reviewed the English literature up to the 1st July 2020 and, excluding single case reports, we considered 13 studies that serologically investigated 220 patients. The presence of specific antibodies was detected in 18 subjects (8,2%): isolated IgA were found in 6 patients, IgA and IgG in 1, isolated IgG in 5, and IgM in 2. In 4 patients, isotypes were not specified. Our review demonstrated a high prevalence of negative serological results in CLL: antibodies were observed only in a few patients, that are even less excluding those with positive IgA, not clearly involved in the pathogenesis of the disease. In conclusion, although it is still uncertain whether CLL are related to SARS‐CoV‐2 infection, patients affected by CLL seem not to be prone to shedding the virus, hence, if they are asymptomatic, we can reassure them, thus avoiding hospital referral This article is protected by copyright. All rights reserved.
- Subjects :
- IgM
IgG
Disease
Dermatology
Antibodies, Viral
Risk Assessment
Asymptomatic
SARS‐CoV‐2
Antibodies
Virus
COVID-19 Serological Testing
Serology
Short Papers
Pathogenesis
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
COVID‐19
Predictive Value of Tests
Risk Factors
Seroepidemiologic Studies
Serological test
Pandemic
Short Paper
Humans
Medicine
biology
Chilblain‐like lesions
SARS-CoV-2
business.industry
pernio‐like lesions
COVID-19
Outbreak
General Medicine
Chilblains
030220 oncology & carcinogenesis
Host-Pathogen Interactions
Immunology
biology.protein
acro‐ischemia
medicine.symptom
Antibody
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 15298019 and 13960296
- Database :
- OpenAIRE
- Journal :
- Dermatologic Therapy
- Accession number :
- edsair.doi.dedup.....333921bdb81ca7b304c8d51f91f7b7fc
- Full Text :
- https://doi.org/10.1111/dth.14229