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Supplementary Figure 3 from Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma

Authors :
John M. Maris
Kristina A. Cole
Bruce Pawel
Andrew C. Wood
Robert W. Schnepp
Giordano Caponigro
Sudha Parasuraman
Sunkyu Kim
Sharon J. Diskin
Edward F. Attiyeh
Erica L. Carpenter
Yimei Li
Daniel Martinez
Lili T. Belcastro
Michael S. Nakazawa
Lori S. Hart
Mike R. Russell
JulieAnn Rader
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary Figure 3 - PDF file 127K, MYCN expression is inversely correlated with LEE011 sensitivity. (A) High mRNA expression of MYCN correlates with low LEE011 IC50s (r = -0.55, p = 0.02). This correlation is further strengthened (r = -0.7, p = 0.003) by the removal of two outliers, SKNSH (IC50 = 148 nM) and its subclone, SY5Y (IC50 = 154 nM). (B) Sensitive cell lines also tend to express higher levels of MYCN protein than resistant cell lines

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....333ed1abcfe4dac959fd817c5e1a1f26