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Intraperitoneal P-32 is not an effective consolidation therapy after a negative second-look laparotomy for epithelial carcinoma of the ovary
- Source :
- Gynecologic oncology. 47(2)
- Publication Year :
- 1992
-
Abstract
- Thirty-four patients with epithelial carcinoma of the ovary were entered into a trial of adjuvant intraperitoneal P-32 following induction chemotherapy and a negative second-look laparotomy. The breakdown by initial Stage was Stage IC, 5; Stage II, 3; Stage III optimal, 22; and Stage III suboptimal, 4. Previous treatment consisted of 4-12 cycles (median 6) of cisplatin or carboplatin-based combination chemotherapy. Fifteen millicuries of P-32 were instilled via a Tenckhoff catheter placed at the time of second-look laparotomy. Because of a 22% incidence of bowel injury in the first 23 patients, the P-32 dose was reduced to 12 mCi in the last 11 patients. To date, there have been no bowel injuries at the lower dose. Eighteen of the 34 (53%) patients have relapsed with a median time to relapse of 20 months and a median follow-up for all patients of 31 months. There has been no difference in the relapse rate between a dose of 12 and 15 mCi. Intraperitoneal P-32 does not appear to reduce the relapse rate following a negative second-look laparotomy. The incidence of bowel injury is dose dependent and is higher than that seen in patients treated as an adjuvant following initial surgery without subsequent chemotherapy or second-look laparotomy.
- Subjects :
- Adult
Chromium
Reoperation
medicine.medical_specialty
medicine.medical_treatment
Brachytherapy
Phosphates
chemistry.chemical_compound
Laparotomy
Chromium Compounds
medicine
Carcinoma
Humans
Life Tables
Stage (cooking)
Radiation Injuries
Peritoneal Cavity
Aged
Neoplasm Staging
Ovarian Neoplasms
Chemotherapy
Epithelioma
business.industry
Obstetrics and Gynecology
Induction chemotherapy
Combination chemotherapy
Dose-Response Relationship, Radiation
Middle Aged
medicine.disease
Combined Modality Therapy
Survival Analysis
Carboplatin
Surgery
Intestines
Oncology
chemistry
Female
business
Phosphorus Radioisotopes
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 47
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gynecologic oncology
- Accession number :
- edsair.doi.dedup.....3352fa0acec4376c029cd773fa00ad19