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Effects of Clarithromycin and Dexamethasone on Mucus Production in Isografted Rat Trachea
- Source :
- Pharmacology. 87:56-62
- Publication Year :
- 2011
- Publisher :
- S. Karger AG, 2011.
-
Abstract
- Objectives: The purpose of this study was to develop an animal model for the study of mucus overproduction and to assess the effect of a 14-membered macrolide antibiotic and a glucocorticoid on lipopolysaccharide (LPS)-induced mucus production. Methods: Tracheas from donor rats were homografted to recipient rats for 4 weeks, and the usefulness of this tracheal homograft model in the study of mucus production was examined. Results: Oral administration of clarithromycin (CAM) to recipient rats for 4 weeks significantly reduced LPS-induced mucus production in the homografted trachea. Dexamethasone administered for 4 weeks also significantly reduced the mucus volume in LPS-treated homografted trachea compared with that in the control rats. The implanted trachea containing control medium was not histologically different from normal trachea. When the medium instilled into the implanted trachea contained 1 µg/ml LPS, the volume and spinability of mucus produced in the tracheal lumen were significantly increased compared to those in the trachea instilled with control medium. Goblet cell metaplasia was also observed in the implanted trachea containing LPS. Conclusions: The present study shows that LPS-administered homografted trachea is a good animal model of chronic hypersecretory diseases of the upper and lower airways. CAM and dexamethasone could be treatment choices in such hypersecretory diseases.
- Subjects :
- Lipopolysaccharides
Male
Pathology
medicine.medical_specialty
Anti-Inflammatory Agents
Severity of Illness Index
Dexamethasone
Oral administration
Clarithromycin
Metaplasia
medicine
Animals
Glucocorticoids
Pharmacology
Goblet cell
Secretory Pathway
Viscosity
business.industry
General Medicine
respiratory system
Mucus
Rats, Inbred F344
Anti-Bacterial Agents
Rats
Trachea
Transplantation
Disease Models, Animal
Transplantation, Isogeneic
medicine.anatomical_structure
Immunology
Goblet Cells
Tracheitis
medicine.symptom
business
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 14230313 and 00317012
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Pharmacology
- Accession number :
- edsair.doi.dedup.....335abf63637ac4bbcca2ecd82f5c238e