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Donor-specific HLA antibodies and graft function in children after renal transplantation
- Source :
- Pediatric Nephrology. 27:1011-1019
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- The presence of circulating donor-specific human leukocyte antigen antibodies (HLA-DSA) has been associated with chronic antibody-mediated rejection, leading to progressive graft dysfunction and poor graft survival. The aim of this study was to investigate the incidence and significance of HLA-DSA in paediatric renal transplantation (RTx) patients. A total of 294 post-transplant serum samples from 123 RTx patients were retrospectively analysed for HLA antibodies. Positive samples were further tested for HLA-DSA by a Luminex Single Antigen bead assay. The antibody findings were correlated to measured glomerular filtration rate (GFR) and clinical outcome. HLA antibodies were detected in half of the routine samples (140/294) taken 1 month to 10 years after RTx, and 40% (62/140) of these were HLA-DSA. Overall, one-third (42/123) of the patients had HLA-DSA, which mostly (65%) reacted against class II antigens. Detection of HLA-DSA was not associated with poor GFR at the time of sampling, and no exceptional deterioration of GFR after the HLA-DSA detection was noted in individual patients regardless of the antibody level. The presence of HLA-DSA in the first 2 years posttransplantation was not associated with poorer graft function later on. Detection of HLA antibodies is common in children after RTx, and this finding, as such, does not predict any deterioration of graft function.
- Subjects :
- Adult
Graft Rejection
Male
Nephrology
medicine.medical_specialty
Time Factors
Adolescent
Renal function
Human leukocyte antigen
Kidney
Risk Assessment
Young Adult
HLA Antigens
Isoantibodies
Risk Factors
Internal medicine
Humans
Medicine
Kidney surgery
Child
Finland
Kidney transplantation
Retrospective Studies
Analysis of Variance
Chi-Square Distribution
biology
business.industry
Graft Survival
Infant
medicine.disease
Kidney Transplantation
Histocompatibility
body regions
Transplantation
Treatment Outcome
Child, Preschool
Pediatrics, Perinatology and Child Health
Immunology
biology.protein
Female
Antibody
business
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 1432198X and 0931041X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Pediatric Nephrology
- Accession number :
- edsair.doi.dedup.....33815b87540041da0623c77d7e3a2363