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Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells
- Source :
- Cytokine. 90
- Publication Year :
- 2016
-
Abstract
- We investigated whether IL-33 is involved in mucus overproduction and goblet cell hyperplasia in eosinophilic chronic rhinosinusitis (ECRS). IL-33 mRNA was significantly higher in the eosinophilic CRS group than in the non-eosinophilic CRS group from human nasal polyps. IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3, and reduces FOXJmRNA. In conclusion, our present study demonstrated that the direct evidence of IL-33 which lead to increase mucin gene and protein expression, as well as goblet cell hyperplasia. This study provides novel insights into the role of IL-33 on mucus overproduction in eosinophilic inflammation of human airways.
- Subjects :
- 0301 basic medicine
Male
Pathology
medicine.medical_specialty
Immunology
Mucin 5AC
digestive system
Biochemistry
03 medical and health sciences
0302 clinical medicine
Gene expression
Eosinophilic
otorhinolaryngologic diseases
medicine
Immunology and Allergy
Humans
Nasal polyps
Sinusitis
030223 otorhinolaryngology
Molecular Biology
Rhinitis
Hyperplasia
Chemistry
Mucin
Forkhead Transcription Factors
Hematology
respiratory system
Middle Aged
medicine.disease
Interleukin-33
Mucus
Molecular biology
Mucin-5B
Interleukin 33
030104 developmental biology
Gene Expression Regulation
Interleukin 13
FOXA3
Female
Goblet Cells
Hepatocyte Nuclear Factor 3-gamma
Subjects
Details
- ISSN :
- 10960023
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....338f093b8ca745a63c1c54232ae9dcad