Statins and Cognition in Parkinson’s Disease

Background The relationship between statins and cognition in Parkinson's disease (PD) is poorly understood. Objectives Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD. Methods Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally. Results At baseline, statin users (SU; N = 129) were older, more likely male, and had shorter PD duration than non-statin users (NSU; N = 184). In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long-term global cognitive (Dementia Rating Scale-2 and MoCA) decline was significantly less in SU.