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Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress
- Source :
- International Journal of Molecular Sciences, Volume 22, Issue 13, International Journal of Molecular Sciences, Vol 22, Iss 7206, p 7206 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- The modern lifestyle brings both excessive fructose consumption and daily exposure to stress which could lead to metabolic disturbances and type 2 diabetes. Muscles are important points of glucose and lipid metabolism, with a crucial role in the maintenance of systemic energy homeostasis. We investigated whether 9-week fructose-enriched diet, with and without exposure to 4-week unpredictable stress, disturbs insulin signaling in the skeletal muscle of male rats and evaluated potential contributory roles of muscle lipid metabolism, glucocorticoid signaling and inflammation. The combination of fructose-enriched diet and stress increased peroxisome proliferator-activated receptors-α and -δ and stimulated lipid uptake, lipolysis and β-oxidation in the muscle of fructose-fed stressed rats. Combination of treatment also decreased systemic insulin sensitivity judged by lower R-QUICKI, and lowered muscle protein content and stimulatory phosphorylations of insulin receptor supstrate-1 and Akt, as well as the level of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor. At the same time, increased levels of protein tyrosine phosphatase-1B, nuclear factor-κB, tumor necrosis factor-α, were observed in the muscle of fructose-fed stressed rats. Based on these results, we propose that decreased glucocorticoid signaling in the skeletal muscle can make a setting for lipid-induced inflammation and the development of insulin resistance in fructose-fed stressed rats.
- Subjects :
- Male
0301 basic medicine
medicine.medical_treatment
fructose
0302 clinical medicine
Glucocorticoid receptor
lipid metabolism
Biology (General)
Spectroscopy
2. Zero hunger
biology
glucocorticoids
Chemistry
General Medicine
Computer Science Applications
medicine.anatomical_structure
Glucocorticoid
Signal Transduction
medicine.drug
medicine.medical_specialty
insulin
QH301-705.5
030209 endocrinology & metabolism
Models, Biological
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Receptors, Glucocorticoid
Insulin resistance
Stress, Physiological
Internal medicine
medicine
Animals
Humans
Rats, Wistar
Physical and Theoretical Chemistry
skeletal muscle
Muscle, Skeletal
Molecular Biology
Protein kinase B
QD1-999
chronic stress
Inflammation
Insulin
Organic Chemistry
Skeletal muscle
Lipid metabolism
medicine.disease
Rats
Insulin receptor
030104 developmental biology
Endocrinology
biology.protein
Insulin Resistance
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....33a2fdc73887daee86e1cddd067820d0
- Full Text :
- https://doi.org/10.3390/ijms22137206