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Projection of Gut Microbiome Pre- and Post-Bariatric Surgery To Predict Surgery Outcome
- Source :
- mSystems, Vol 6, Iss 3 (2021), mSystems
- Publication Year :
- 2021
- Publisher :
- American Society for Microbiology, 2021.
-
Abstract
- Bariatric surgery is often the preferred method to resolve obesity and diabetes, with ∼800,000 cases worldwide yearly and high outcome variability. The ability to predict the long-term body mass index (BMI) change following surgery has important implications for individuals and the health care system in general. Given the tight connection between eating habits, sugar consumption, BMI, and the gut microbiome, we tested whether the microbiome before any treatment is associated with different treatment outcomes, as well as other intakes (high-density lipoproteins [HDL], triglycerides, etc.). A projection of the gut microbiome composition of obese (sampled before and after bariatric surgery) and lean patients into principal components was performed, and the relation between this projection and surgery outcome was studied. The projection revealed three different microbiome profiles belonging to lean, obese, and obese individuals who underwent bariatric surgery, with the postsurgery microbiome more different from the lean microbiome than the obese microbiome. The same projection allowed for a prediction of BMI loss following bariatric surgery, using only the presurgery microbiome. The microbial changes following surgery were an increase in the relative abundance of Proteobacteria and Fusobacteria and a decrease in Firmicutes. The gut microbiome can be decomposed into main components depicting the patient's development and predicting in advance the outcome. Those may be translated into the better clinical management of obese individuals planning to undergo metabolic surgery. IMPORTANCE BMI and diabetes can affect the gut microbiome composition. Bariatric surgery has large variabilities in the outcome. The microbiome was previously shown to be a good predictor for multiple diseases. We analyzed here the gut microbiome before and after bariatric surgery and showed the following. (i) The microbiome before surgery can be used to predict surgery outcomes. (ii) The postsurgery microbiome drifts further away from the lean microbiome than the microbiome of the presurgery obese patients. These results can lead to a microbiome-based presurgery decision whether to perform surgery.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
obesity
Physiology
bariatric surgery
030209 endocrinology & metabolism
Sugar consumption
Biochemistry
Microbiology
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Genetics
Medicine
Microbiome
Molecular Biology
Pre and post
Ecology, Evolution, Behavior and Systematics
business.industry
fungi
food and beverages
medicine.disease
Obesity
Gut microbiome
QR1-502
Computer Science Applications
Surgery
030104 developmental biology
machine learning
Modeling and Simulation
Surgery outcome
business
Body mass index
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23795077
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- mSystems
- Accession number :
- edsair.doi.dedup.....33b0d181f1e1abff96f18a039fe5375e