Back to Search
Start Over
Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans
- Source :
- Diabetes. 49(3)
- Publication Year :
- 2000
-
Abstract
- Hyperinsulinemia predicts the development of type 2 diabetes, and family studies suggest that insulin levels are regulated in part by genes. We conducted a genome-wide scan to detect genes influencing variation in fasting serum insulin concentrations in 391 nondiabetic individuals from 10 large multigenerational families. Approximately 380 microsatellite markers with an average spacing of 10 cM were genotyped in all study subjects. Insulin concentrations measured by radioimmunoassay were transformed by their natural logarithms before analysis. In multipoint analysis, peak evidence for linkage occurred on chromosome 3p approximately 109 cM from pter in the region of 3p14.2-p14.1. The multipoint logarithm of odds (LOD) score was 3.07, occurring in the region flanked by markers D3S1600 and D3S1285 (P value by simulation
- Subjects :
- Adult
Male
Candidate gene
medicine.medical_specialty
Genotype
Genetic Linkage
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Type 2 diabetes
Biology
Genetic linkage
Internal medicine
Mexican Americans
Internal Medicine
medicine
Hyperinsulinemia
Humans
Insulin
Genetics
Osmolar Concentration
Chromosome
Radioimmunoassay
Fasting
medicine.disease
Endocrinology
Microsatellite
Female
Chromosomes, Human, Pair 3
Insulin Resistance
Lod Score
Microsatellite Repeats
Subjects
Details
- ISSN :
- 00121797
- Volume :
- 49
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....33dd5e35f1686fceac2786f19d4b6424