Back to Search
Start Over
Primary surgery versus primary radiation therapy for FIGO stages I–II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study
- Source :
- Gynecologic Oncology. 137:468-473
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Objective : To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods : We reviewed the medical records and histological files of 144 patients with FIGO stages IA–IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results : There were 110 patients receiving primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P =0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor ≤2cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5cycles of platinum-based chemotherapy ( n =14, including 12 stages IB2–IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery ( n =97, including 40 stages IB2–IIB) ( P =0.046). Conclusions : None of the 9 patients with cervical tumor ≤2cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I–II, primary radiation therapy with aggressive chemotherapy was associated with better survival than surgery.
- Subjects :
- Adult
medicine.medical_specialty
medicine.medical_treatment
Taiwan
Uterine Cervical Neoplasms
Gynecologic oncology
Small-cell carcinoma
Disease-Free Survival
Cohort Studies
medicine
Humans
Carcinoma, Small Cell
Radical Hysterectomy
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Cervical cancer
Chemotherapy
business.industry
Medical record
Obstetrics and Gynecology
Retrospective cohort study
Middle Aged
medicine.disease
Surgery
Radiation therapy
Oncology
Female
business
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....3424e4296c9f74cf7194311b1548e9cc