Apolipoprotein E gene polymorphism in Egyptian acute coronary syndrome patients

Authors :: Nayl Abd Elhamed Zaki
Aida A. Mahmoud
Laila M. Yousef
Source :: Egyptian Journal of Medical Human Genetics; Vol 17, No 1 (2016); 99-103, Egyptian Journal of Medical Human Genetics, Vol 17, Iss 1, Pp 99-103 (2016)
Publisher :: The Authors. Production and hosting by Elsevier B.V.
Abstract: Background : Apolipoprotein E (apo E) gene polymorphism was found to be associated with coronary artery disease in several studies. In this investigation, we aimed to study the association between apo E gene polymorphism and acute coronary syndrome in Egyptian population. Subjects and methods : The study included 200 patients with acute coronary syndrome (myocardial infarction and unstable angina), and 100 healthy controls. Anthropometric, clinical and lipid profile parameters were evaluated. Apo E genotyping was carried out using sequence-specific-primer (SSP)-PCR methodology. Results : Є3/4 genotype frequency was higher in the patients than in the controls (P