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Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems

Authors :
Koushik Guha
Girija S. Kondavitee
Ashok K. Puli
Hamza Mohammed
Srinivasa Rao Karumuri
Ameen Einsanwi
Source :
IET Nanobiotechnology, IET Nanobiotechnology, Vol 15, Iss 5, Pp 484-491 (2021)
Publication Year :
2021
Publisher :
Institution of Engineering and Technology (IET), 2021.

Abstract

This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in the application of Bio‐MEMS. These microneedles are well suitable for a MEMS‐based micropump in the drug delivery systems. It is an essential part of the micropump through which the drug is released into the patient’s body. The proposed microneedles can withstand a stress of 23 MPa and 20 KPa. An extensive investigation on selection of material for the microneedle is carried out to meet the requirements of the biocompatibility and high yield, as well as tensile strength. As mighty drugs such as vasopressin, atropine and digoxin are administered in large quantities, the microneedle is designed so as to deliver 800 µl of drug, with each microneedle delivering 90 µl. in a 3 3 array. 3 × 3 array releasing 90 µl.

Details

ISSN :
1751875X and 17518741
Volume :
15
Database :
OpenAIRE
Journal :
IET Nanobiotechnology
Accession number :
edsair.doi.dedup.....345595cc61ebd4274fb1b78db35c1cab
Full Text :
https://doi.org/10.1049/nbt2.12013