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Descriptive Analysis of Everolimus Conversion in Liver Transplant Recipients With Malignant Neoplastic Disease
- Source :
- Transplantation Proceedings. 52:553-555
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background Calcineurin inhibitors are associated with the development of de novo tumors and increased recurrence of hepatocellular carcinoma after liver transplant. It has been suggested that mammalian target of rapamycin inhibitors (everolimus [EVR]) may improve prognosis. We analyzed our experience on the use of EVR in malignant neoplasms in liver transplantation. Methods. We performed a retrospective descriptive analysis of 477 transplants performed between 2002 and 2019 at Virgen de las Nieves Hospital. A total of 100 patients received EVR; 23 transplants were because of tumor disease (23%), with de novo tumor in 12 patients and hepatocarcinoma in 11. The statistical study was carried out using the statistical program SPSS 17.0 software. Results The study included 18 male patients (78.3%) and 5 female patients (21.7%) with an average age of 59.67 years. The most common indications of liver transplant have been alcoholic cirrhosis in 39% and hepatitis C virus cirrhosis in 21.7%. De novo tumors were lung neoplasm in 4 patients (33.3%), lymphoma in 2 patients(16.7%), oropharynx in 2 patients (16.7%), skin tumors in 2 patients (16.7%), and a kidney tumor (8.3%) in 1 patient. As for hepatocellular carcinoma, 8 patients met Milan criteria on the explant (61.5%). Tacrolimus was discontinued in all cases. The average onset time of post-transplant EVR was 2231.42 days in the de novo neoplasms and 307.45 days in those receiving transplants because of hepatocellular carcinoma (P = .05). We observed 5 deaths (21.7%). Conclusion Although the beneficial long-term role of EVR in liver transplant recipients with tumor disease is not demonstrated, it is used by most transplant units, both in de novo neoplasms and those receiving transplants because of hepatocellular carcinoma.
- Subjects :
- Adult
Male
medicine.medical_specialty
Alcoholic liver disease
Carcinoma, Hepatocellular
Cirrhosis
medicine.medical_treatment
Calcineurin Inhibitors
Antineoplastic Agents
Milan criteria
Liver transplantation
Gastroenterology
Postoperative Complications
Internal medicine
medicine
Carcinoma
Humans
Everolimus
Retrospective Studies
Transplantation
business.industry
Liver Neoplasms
Middle Aged
medicine.disease
Tacrolimus
Liver Transplantation
Treatment Outcome
Hepatocellular carcinoma
Female
Surgery
Neoplasm Recurrence, Local
business
medicine.drug
Subjects
Details
- ISSN :
- 00411345
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....34771cd6b9131d8c2a2e7dc2084c2efa