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Oviductal Telocytes in Patients with Uterine Myoma
- Source :
- Biomedicines, Vol 9, Iss 1060, p 1060 (2021), Biomedicines, Volume 9, Issue 8
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Tubal factor infertility occurs in 30–35% of infertile pairs and may be caused by impaired muscular contractility and ciliary beating as well as immunological imbalance and chronic inflammation. Newly discovered telocytes (TCs) have a wide palette of features, which play a role in oviduct physiology. We have observed tissue samples from human fallopian tubes in patients with and without uterine myoma by immunolabelling. According to the immunohistochemical co-expression of markers, it has been determined that TCs are engaged in a wide range of physiological processes, including local innervation, sensitivity to hypoxia, regulation of calcium, and sex steroid hormones balances. Due to the proximity of NOS- and ChAT-positive nerve fibers and the expression of ion channels markers, tubal TCs might be considered conductor cells. Additionally, their integration in contractions and cilia physiology in the context of fertility has been revealed. We have observed the difference in telocytes expression in the human oviduct between groups of patients and attempted to describe this population of cells specifically in the case of infertility development, a clinically relevant avenue for further studies.
- Subjects :
- Infertility
Pathology
medicine.medical_specialty
PDGFRα
oviduct
QH301-705.5
Population
Medicine (miscellaneous)
Context (language use)
telocytes
muscular contractility
Article
General Biochemistry, Genetics and Molecular Biology
Contractility
medicine
Biology (General)
education
education.field_of_study
business.industry
Cilium
Tubal factor infertility
medicine.disease
Oviduct
Immunohistochemistry
CD34
business
infertility
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 9
- Issue :
- 1060
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....348dbd186dafc443d81e4370814a3b76