Back to Search Start Over

Added diagnostic value of respiratory-gated 4D 18F–FDG PET/CT in the detection of liver lesions: a multicenter study

Authors :
Annibale Versari
Claudio Landoni
Cinzia Crivellaro
Sergio Todde
Luca Guerra
Valentino Bettinardi
Miroslaw Dziuk
Federica Fioroni
Sabrina Morzenti
Elena De Ponti
Federica Elisei
Guillaume Nodari
Renée Ahond-Vionnet
Konrad Tkaczewski
Maria Picchio
Crivellaro, C
De Ponti, E
Elisei, F
Morzenti, S
Picchio, M
Bettinardi, V
Versari, A
Fioroni, F
Dziuk, M
Tkaczewski, K
Ahond-Vionnet, R
Nodari, G
Todde, S
Landoni, C
Guerra, L
Crivellaro, Cinzia
De Ponti, Elena
Elisei, Federica
Morzenti, Sabrina
Picchio, Maria
Bettinardi, Valentino
Versari, Annibale
Fioroni, Federica
Dziuk, Miroslaw
Tkaczewski, Konrad
Ahond-Vionnet, Renée
Nodari, Guillaume
Todde, Sergio
Landoni, Claudio
Guerra, Luca
Publication Year :
2018
Publisher :
Springer Berlin Heidelberg, 2018.

Abstract

Purpose: The aim of the present study was to evaluate the added diagnostic value of respiratory-gated 4D18F–FDG PET/CT in liver lesion detection and characterization in a European multicenter retrospective study. Methods: Fifty-six oncological patients (29 males and 27 females, mean age, 61.2 ± 11.2 years) from five European centers, submitted to standard 3D–PET/CT and liver 4D–PET/CT were retrospectively evaluated. Based on visual analysis, liver PET/CT findings were scored as positive, negative, or equivocal both in 3D and 4D PET/CT. The impact of 4D–PET/CT on the confidence in classifying liver lesions was assessed. PET/CT findings were compared to histology and clinical follow-up as standard reference and diagnostic accuracy was calculated for both techniques. At semi-quantitative analysis, SUVmax was calculated for each detected lesion in 3D and 4D–PET/CT. Results: Overall, 72 liver lesions were considered for the analysis. Based on visual analysis in 3D–PET/CT, 32/72 (44.4%) lesions were considered positive, 21/72 (29.2%) negative, and 19/72 (26.4%) equivocal, while in 4D–PET/CT 48/72 (66.7%) lesions were defined positive, 23/72 (31.9%) negative, and 1/72 (1.4%) equivocal. 4D–PET/CT findings increased the confidence in lesion definition in 37/72 lesions (51.4%). Considering 3D equivocal lesions as positive, sensitivity, specificity, and accuracy were 88.9, 70.0, and 83.1%, respectively, while the same figures were 67.7, 90.0, and 73.8% if 3D equivocal findings were included as negative. 4D–PET/CT sensitivity, specificity, and accuracy were 97.8, 90.0, and 95.4%, respectively, considering equivocal lesions as positive and 95.6, 90.0, and 93.8% considering equivocal lesions as negative. The SUVmax of the liver lesions in 4D–PET (mean ± SD, 6.9 ± 3.2) was significantly higher (pÂ

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....3493d2d58c1394f1693891ff3aab57c1