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Added diagnostic value of respiratory-gated 4D 18F–FDG PET/CT in the detection of liver lesions: a multicenter study
- Publication Year :
- 2018
- Publisher :
- Springer Berlin Heidelberg, 2018.
-
Abstract
- Purpose: The aim of the present study was to evaluate the added diagnostic value of respiratory-gated 4D18FâFDG PET/CT in liver lesion detection and characterization in a European multicenter retrospective study. Methods: Fifty-six oncological patients (29 males and 27 females, mean age, 61.2 ± 11.2 years) from five European centers, submitted to standard 3DâPET/CT and liver 4DâPET/CT were retrospectively evaluated. Based on visual analysis, liver PET/CT findings were scored as positive, negative, or equivocal both in 3D and 4D PET/CT. The impact of 4DâPET/CT on the confidence in classifying liver lesions was assessed. PET/CT findings were compared to histology and clinical follow-up as standard reference and diagnostic accuracy was calculated for both techniques. At semi-quantitative analysis, SUVmax was calculated for each detected lesion in 3D and 4DâPET/CT. Results: Overall, 72 liver lesions were considered for the analysis. Based on visual analysis in 3DâPET/CT, 32/72 (44.4%) lesions were considered positive, 21/72 (29.2%) negative, and 19/72 (26.4%) equivocal, while in 4DâPET/CT 48/72 (66.7%) lesions were defined positive, 23/72 (31.9%) negative, and 1/72 (1.4%) equivocal. 4DâPET/CT findings increased the confidence in lesion definition in 37/72 lesions (51.4%). Considering 3D equivocal lesions as positive, sensitivity, specificity, and accuracy were 88.9, 70.0, and 83.1%, respectively, while the same figures were 67.7, 90.0, and 73.8% if 3D equivocal findings were included as negative. 4DâPET/CT sensitivity, specificity, and accuracy were 97.8, 90.0, and 95.4%, respectively, considering equivocal lesions as positive and 95.6, 90.0, and 93.8% considering equivocal lesions as negative. The SUVmax of the liver lesions in 4DâPET (mean ± SD, 6.9 ± 3.2) was significantly higher (pÂ
- Subjects :
- Male
medicine.medical_specialty
Respiratory-Gated Imaging Techniques
Positron emission tomography
Radiology, Nuclear Medicine and Imaging
030218 nuclear medicine & medical imaging
Lesion
Respiratory gating
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
medicine
Humans
Respiratory system
Four-Dimensional Computed Tomography
Computed tomography
Aged
medicine.diagnostic_test
business.industry
Liver Neoplasms
Histology
Retrospective cohort study
General Medicine
Middle Aged
Liver lesion detection/characterization
SUV
Liver lesion
Multicenter study
030220 oncology & carcinogenesis
Fdg pet ct
Female
Radiology
medicine.symptom
Radiopharmaceuticals
business
Nuclear medicine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....3493d2d58c1394f1693891ff3aab57c1