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Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis
- Source :
- Journal of Rheumatology, 42(4), 572-579
- Publication Year :
- 2014
-
Abstract
- Objective.Anti-carbamylated protein (anti-CarP) antibodies could further elucidate early rheumatoid arthritis (RA) pathogenesis and predict clinical disease. We compared the diagnostic accuracy of anti-CarP antibodies for future RA to other RA-related antibodies in military personnel.Methods.Stored pre-RA diagnosis serum samples from 76 RA cases were tested for anti-CarP fetal calf serum (FCS), anti-CarP fibrinogen (Fib), anticyclic citrullinated peptide antibodies version 2 (anti-CCP2), rheumatoid factor-nephelometry (RF-Neph), and RF isotypes [immunoglobulin M (IgM), IgG, and IgA]. Positivity for all antibodies was determined as ≥ 2 SD of log-transformed means from controls. Relationships between autoantibodies and future RA were assessed in prediagnosis serum for all RA cases compared to controls using sensitivity, specificity, and logistic regression. Differences in diagnostic accuracy between antibody combinations were assessed using comparisons of area under the curves (AUC).Results.Anti-CarP-FCS was 26% sensitive and 95% specific for future RA, whereas anti-CarP-Fib was 16% sensitive and 95% specific for future RA. Anti-CarP-FCS positivity was associated with future RA, while anti-CarP-Fib trended toward association. The antibody combination of anti-CCP2 and/or ≥ 2 RF (RF-Neph and/or RF-isotypes) resulted in an AUC of 0.72 for future RA, where the AUC was 0.71 with the addition of anti-CarP-FCS to this prior combination.Conclusion.Adding anti-CarP-FCS to antibody combinations did not improve AUC. However, anti-CarP-FCS was associated with future onset of RA, and was present in prediagnosis serum in ∼10% of RA cases negative for anti-CCP2 but positive for RF.
- Subjects :
- Adult
Male
Immunology
Immunoglobulins
Fibrinogen
Logistic regression
Peptides, Cyclic
Sensitivity and Specificity
Article
Pathogenesis
Arthritis, Rheumatoid
Rheumatology
Rheumatoid Factor
medicine
Immunology and Allergy
EPIDEMIOLOGY
Humans
RHEUMATOID ARTHRITIS
Autoantibodies
Fetus
biology
business.industry
Autoantibody
Middle Aged
medicine.disease
Immunoglobulin M
Rheumatoid arthritis
biology.protein
Female
sense organs
Antibody
business
medicine.drug
Subjects
Details
- ISSN :
- 0315162X
- Volume :
- 42
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of rheumatology
- Accession number :
- edsair.doi.dedup.....34a74b19e77ae201393d01c236d73d8f