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Chronic Early-Stage Ocular Cicatricial Pemphigoid

Authors :
Lora R. Dagi Glass
Danielle Trief
Sonya Besagar
Ashley O London
Meghan Pooja Jairam
Source :
Ophthalmic plastic and reconstructive surgery. 37(6)
Publication Year :
2021

Abstract

Ocular cicatricial pemphigoid (OCP) represents an insidious, autoimmune-mediated disease of the conjunctiva, initially presenting as chronic conjunctivitis and progressing to fibrosis, cicatrization, and eventually blindness secondary to corneal keratinization. This series reports 3 cases presenting with chronic conjunctivitis lasting an average of 10 years without cicatrix formation, ultimately diagnosed as OCP based on direct immunofluorescence of conjunctival biopsy samples. This chronic conjunctivitis without fibrosis suggests the possibility of an OCP subtype with a prolonged early stage or prodrome prior to cicatrization, which may benefit from early diagnosis and treatment to prevent complications of this disease.

Details

ISSN :
15372677
Volume :
37
Issue :
6
Database :
OpenAIRE
Journal :
Ophthalmic plastic and reconstructive surgery
Accession number :
edsair.doi.dedup.....34becc6936e1eb075daa9d8c46e8e8cb