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Salivary β2- microglobulin Levels in Patients with Erosive Oral Lichen Planus and Squamous Cell Carcinoma
- Source :
- BMC Research Notes, Vol 13, Iss 1, Pp 1-5 (2020), BMC Research Notes
- Publication Year :
- 2020
- Publisher :
- Research Square Platform LLC, 2020.
-
Abstract
- Objectives β2 microglobulin, as a biomarker, is used for the diagnosis of oral malignant and pre-malignant lesions. The components of the microglobulin system can directly or indirectly help grow and develop tumors. The present study aims to compare beta-2 microglobulin levels in patients with lichen planus of the esophagus, oral squamous cell carcinoma, and healthy individuals. Further, it evaluated the salivary β2-microglobulin level in malignant and pre-malignant lesions. Oral lichen planus (OLP) is a chronic skin-mucus disorder. Of the total 75 patients referred to Oral Medicine at Dentistry School of Zahedan University of Medical Sciences, 25 were healthy and 25 had oral lichen planus (OLP) and the rest had squamous cell carcinoma (SCC). To collect the saliva samples, unstimulated spitting was used. They were collected between 9 and 12 a.m. Salivary beta2 microglobulin was recorded based on the factory instructions by ELISA optical density method with 450 nm wavelength for each sample. The data were analyzed using descriptive, Kruskal–Wallis and Mann–Whitney and Pearson’s correlation coefficient (SPSS 21). Results The salivary β2 microglobulin level in patients with squamous cell carcinoma (SCC) and oral lichen plan (OLP) is significantly higher than that in healthy group. Thus, this index is used for assessing early malignant transformation and oral pre-malignant lesion.
- Subjects :
- Adult
Saliva
medicine.medical_specialty
lcsh:Medicine
Gastroenterology
OLP
General Biochemistry, Genetics and Molecular Biology
Malignant transformation
Lesion
03 medical and health sciences
Esophagus
0302 clinical medicine
stomatognathic system
Internal medicine
Biomarkers, Tumor
medicine
Humans
lcsh:Science (General)
lcsh:QH301-705.5
Beta-2 microglobulin
business.industry
Salivary β2-microglobulin
lcsh:R
030206 dentistry
General Medicine
medicine.disease
SCC
Research Note
stomatognathic diseases
Cell Transformation, Neoplastic
Cross-Sectional Studies
medicine.anatomical_structure
lcsh:Biology (General)
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Biomarker (medicine)
Mouth Neoplasms
Oral lichen planus
medicine.symptom
beta 2-Microglobulin
business
Precancerous Conditions
Oral medicine
Lichen Planus, Oral
lcsh:Q1-390
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- BMC Research Notes, Vol 13, Iss 1, Pp 1-5 (2020), BMC Research Notes
- Accession number :
- edsair.doi.dedup.....34c25d4da15c277b26a0f44c981aa024