Back to Search Start Over

Acute Kidney Injury Is Associated With In-hospital Mortality in Older Patients With COVID-19

Authors :
Min Xie
Ling Cheng
Yuanyuan Li
Hongyu Gao
Lun Zhou
Qi Yan
Yuting Chen
Kaixin Song
Weiwei Yu
Cuntai Zhang
Yi Yang
Peiyuan Zuo
Yue Dai
Yongsheng Li
Source :
The Journals of Gerontology: Series A, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publication Year :
2020
Publisher :
Oxford University Press (OUP), 2020.

Abstract

Background The epidemic of COVID-19 presents a special threat to older adults. However, information on kidney damage in older patients with COVID-19 is limited. Acute kidney injury (AKI) is common in hospitalized adults and associated with poor prognosis. We sought to explore the association between AKI and mortality in older patients with COVID-19. Methods We conducted a retrospective, observational cohort study in a large tertiary care university hospital in Wuhan, China. All consecutive inpatients older than 65 years with COVID-19 were enrolled in this cohort. Demographic data, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. Data were compared between patients with AKI and without AKI. The association between AKI and mortality was analyzed. Results Of 1764 in-hospital patients, 882 older adult cases were included in this cohort. The median age was 71 years (interquartile range: 68–77), 440 (49.9%) were men. The most presented comorbidity was cardiovascular diseases (58.2%), followed by diabetes (31.4%). Of 882 older patients, 115 (13%) developed AKI and 128 (14.5%) died. Patients with AKI had higher mortality than those without AKI (68 [59.1%] vs 60 [7.8%]; p Conclusions Acute kidney injury is not an uncommon complication in older patients with COVID-19 but is associated with a high risk of death. Physicians should be aware of the risk of AKI in older patients with COVID-19.

Details

Language :
English
ISSN :
1758535X and 10795006
Database :
OpenAIRE
Journal :
The Journals of Gerontology: Series A
Accession number :
edsair.doi.dedup.....34dec663c5a566c257f1607cc1e01686
Full Text :
https://doi.org/10.1093/gerona/glaa181