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Renal Tubular Acidosis in Patients with Systemic Lupus Erythematosus
Renal Tubular Acidosis in Patients with Systemic Lupus Erythematosus
- Source :
- Kidney & Blood Pressure Research, Pp 1-7 (2020)
- Publication Year :
- 2020
- Publisher :
- S. Karger AG, 2020.
-
Abstract
- Objective: Renal tubular acidosis (RTA) is a clinical manifestation that occurs with insufficiency in restoring bicarbonate or disruption in hydrogen ion elimination as a result of a disruption in tubulus functions, causing normal anion gap-opening metabolic acidosis. In the present study, we aimed to investigate the prevalence of RTA in the largest systemic lupus erythematosus (SLE) patient population to date. Materials and Methods: SLE patients, who were followed up in 2 different healthcare centers, were included. Patients with metabolic acidosis (pH 3 Results: A total of 108 patients were included in the present study. The mean age of the patients was 41.5 ± 1.2 and 87% were female. The SLE diagnosis duration was 75 ± 5 months. The mean creatinine value was 0.6 ± 0.1 mg/dL and the mean eGFR was 111 ± 2 mL/min. According to the blood gas analysis, 18 patients (16.7% of the total) had RTA. Sixteen of these patients had type 1 RTA and 2 had type 2 RTA; type 4 RTA was not determined in any of the patients. Conclusion: RTA should be considered in SLE patients even if they have normal eGFR values. This is the largest study to examine the prevalence of RTA in SLE patients in the literature.
- Subjects :
- Adult
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
viruses
Anion gap
Renal function
lcsh:RC870-923
Gastroenterology
Renal tubular acidosis
chemistry.chemical_compound
systemic lupus erythematosus
Internal medicine
lcsh:Dermatology
medicine
Humans
Lupus Erythematosus, Systemic
Acid-Base Equilibrium
glomerular filtration rate
Creatinine
Proteinuria
business.industry
Metabolic acidosis
Acidosis, Renal Tubular
General Medicine
Venous blood
Middle Aged
biochemical phenomena, metabolism, and nutrition
lcsh:RL1-803
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
chemistry
lcsh:RC666-701
Nephrology
Urine anion gap
Female
proteinuria
renal tubular acidosis
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14230143 and 14204096
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Kidney and Blood Pressure Research
- Accession number :
- edsair.doi.dedup.....34ef4791d781c8f6815dd9c61b536c7c
- Full Text :
- https://doi.org/10.1159/000509841