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Effect of perchlorate and thiocyanate exposure on thyroid function of pregnant women from South-West England: a cohort study
- Source :
- Thyroid Research, Vol 11, Iss 1, Pp 1-7 (2018), Thyroid Research
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair fetal neurological development. As perchlorate and thiocyanate inhibit sodium-iodide symporter reducing the transport of iodine from circulation into the thyroid follicular cells, environmental exposure to these substances in pregnancy may impair maternal thyroid hormone synthesis. We aimed to explore the impact of perchlorate and thiocyanate exposure on thyroid status in a cohort of pregnant mothers from South West England. Methods Urine samples were obtained from 308 women participating in a study of breech presentation in late pregnancy. They had no known thyroid disease and a singleton pregnancy at 36–38 weeks gestation. Samples were analysed for urinary concentrations of iodine (UIC), perchlorate (UPC) and thiocyanate (UTC). Blood samples were taken for free T4 (FT4), thyrotropin (TSH) and thyroid peroxidase antibodies (TPO-Ab). Baseline data included age, parity, smoking status, ethnicity and BMI at booking. Following delivery, data on offspring’s sex, gestational age at birth and birthweight were collected. Results Participants had a mean (SD) age 31 (5) years, median (IQR) BMI 24.4 (22.0, 28.3) kg/m2, 42% were primiparous, 10% were smokers, and 96% were Caucasian. Median UIC was 88 μg/l, and 174/308 (57%) women had UIC
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Perchlorate
030209 endocrinology & metabolism
010501 environmental sciences
01 natural sciences
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Thyroid peroxidase
Pregnancy
Birth weight
medicine
0105 earth and related environmental sciences
Thyroid
lcsh:RC648-665
biology
Endocrine and Autonomic Systems
Obstetrics
business.industry
Research
Thyroid disease
Gestational age
Environmental exposure
medicine.disease
Iodine deficiency
medicine.anatomical_structure
Thiocyanate
biology.protein
Thyroid function
business
Iodine
Subjects
Details
- Language :
- English
- ISSN :
- 17566614
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Thyroid Research
- Accession number :
- edsair.doi.dedup.....3508222bd7b192dd2497ffc15dc65832