Back to Search
Start Over
Reduced bone mineral density in Chinese children with phenylketonuria
- Source :
- Journal of Pediatric Endocrinology and Metabolism. 30
- Publication Year :
- 2017
- Publisher :
- Walter de Gruyter GmbH, 2017.
-
Abstract
- Background:Phenylketonuria (PKU) is an autosomal recessive metabolic disorder. Dietary control of classic PKU needs restriction of natural proteins. The diet results in unbalanced nutrition, which might affect the physical development of the patients. Our aim was to evaluate bone mineral density (BMD) in children with PKU.Methods:To investigate the BMD of children with PKU, 41 children with PKU and 64 healthy controls were recruited (all 3–4 years of age). Body weight and height, BMD, Phe blood levels, thyroid function, calcium, phosphorus, iron metabolism markers, and vitamin D3 were measured.Results:Body height and BMD of patients were lower than in controls. The BMD of controls was positively associated with age, body weight and height. In patients, BMD was positively associated with body weight. There was no correlation between Phe blood levels and BMD in patients. Blood levels of alkaline phosphatase were higher in patients compared to controls. Blood calcium levels were higher in 4-year-old patients, while the body weight was lower compared to controls. Thyroid function, iron metabolism markers, vitamin D3 levels and IGF-1 levels were normal.Conclusions:Reduced BMD was observed in children with phenylketonuria, but the exact reasons for this remain to be elucidated.
- Subjects :
- Male
Vitamin
China
medicine.medical_specialty
Bone density
Phenylketonurias
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Bone Density
Internal medicine
Humans
Medicine
030212 general & internal medicine
Bone mineral
business.industry
Metabolic disorder
Case-control study
Prognosis
medicine.disease
chemistry
Case-Control Studies
Child, Preschool
Pediatrics, Perinatology and Child Health
Alkaline phosphatase
Female
Bone Diseases
Thyroid function
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 21910251 and 0334018X
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....350c3d485de542b713993bee3cd2d70a