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Crystal structures of the components of theStaphylococcus aureusleukotoxin ED
- Source :
- Acta Crystallographica. Section D, Structural Biology
- Publication Year :
- 2016
- Publisher :
- International Union of Crystallography (IUCr), 2016.
-
Abstract
- Crystal structures of LukE and LukD from S. aureus are reported at 3.20 and 1.70 Å resolution, respectively.<br />Staphylococcal leukotoxins are a family of β-barrel, bicomponent, pore-forming toxins with membrane-damaging functions. These bacterial exotoxins share sequence and structural homology and target several host-cell types. Leukotoxin ED (LukED) is one of these bicomponent pore-forming toxins that Staphylococcus aureus produces in order to suppress the ability of the host to contain the infection. The recent delineation of the important role that LukED plays in S. aureus pathogenesis and the identification of its protein receptors, combined with its presence in S. aureus methicillin-resistant epidemic strains, establish this leukocidin as a possible target for the development of novel therapeutics. Here, the crystal structures of the water-soluble LukE and LukD components of LukED have been determined. The two structures illustrate the tertiary-structural variability with respect to the other leukotoxins while retaining the conservation of the residues involved in the interaction of the protomers in the bipartite leukotoxin in the pore complex.
- Subjects :
- Models, Molecular
0301 basic medicine
Staphylococcus aureus
Pore complex
pore-forming toxins
Protein Conformation
Leukocidin
Exotoxins
Sequence alignment
Biology
medicine.disease_cause
Staphylococcal infections
Microbiology
03 medical and health sciences
Protein structure
Bacterial Proteins
Structural Biology
leukotoxin
medicine
Humans
Amino Acid Sequence
LukE
LukD
Peptide sequence
Pore-forming toxin
Staphylococcal Infections
medicine.disease
Research Papers
030104 developmental biology
Sequence Alignment
Subjects
Details
- ISSN :
- 20597983
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Acta Crystallographica Section D Structural Biology
- Accession number :
- edsair.doi.dedup.....351282441022984caca65699261554c8