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Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics
- Source :
- Trends in Cell Biology. 28:67-76
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Membrane organelles comprise both proteins and lipids. Remodeling of these membrane structures is controlled by interactions between specific proteins and lipids. Mitochondrial structure and function depend on regulated fusion and the division of both the outer and inner membranes. Here we discuss recent advances in the regulation of mitochondrial dynamics by two critical phospholipids, phosphatidic acid (PA) and cardiolipin (CL). These two lipids interact with the core components of mitochondrial fusion and division (Opa1, mitofusin, and Drp1) to activate and inhibit these dynamin-related GTPases. Moreover, lipid-modifying enzymes such as phospholipases and lipid phosphatases may organize local lipid composition to spatially and temporarily coordinate a balance between fusion and division to establish mitochondrial morphology.
- Subjects :
- 0301 basic medicine
Cardiolipins
Phosphatidic Acids
Biology
Mitochondrial Dynamics
Article
GTP Phosphohydrolases
Mitochondrial Proteins
03 medical and health sciences
chemistry.chemical_compound
Mitochondrial membrane transport protein
0302 clinical medicine
Cardiolipin
Humans
Inner mitochondrial membrane
Cell Biology
Phosphatidic acid
Mitochondrial carrier
Mitochondria
Cell biology
030104 developmental biology
chemistry
mitochondrial fusion
Mitochondrial Membranes
Translocase of the inner membrane
biology.protein
lipids (amino acids, peptides, and proteins)
ATP–ADP translocase
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09628924
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Trends in Cell Biology
- Accession number :
- edsair.doi.dedup.....3516a789ffd292d1a8086945318c3c6f