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Pharmacologic Factors Associated with Gentamicin Nephrotoxicity in Rabbits
- Source :
- Journal of Infectious Diseases. 135:952-956
- Publication Year :
- 1977
- Publisher :
- Oxford University Press (OUP), 1977.
-
Abstract
- Nine rabbits were given subcutaneous doses of 7.5 mg of gentamicin/kg every 24 hr, and nine were given 2.5 mg of gentamicin/kg every 8 hr for three weeks or longer. Renal function was evaluated by monitoring of the concentration of creatinine in serum and the rate of clearance of gentamicin from serum. In the animals receiving the 8-hr divided dosage, a deterioration of renal function as early as day 7 was demonstrated by the rate of clearance of gentamicin, and deterioration by day 21 was evidenced by the concentration of creatinine in serum; the renal function of the animals receiving the single daily dose was unchanged. There was no relationship between peak or trough concentrations of gentamicin in serum and the development of nephrotoxicity. The animals receiving the 8-hr dosages had a significantly longer daily duration of exposure to concentrations of greater than or equal to 0.1, greater than or equal to 1.0, greater than or equal to 2.0, and greater than or equal to 3.0 microng of gentamicin/ml in serum than did animals receiving the daily dosage.
- Subjects :
- Male
Creatinine
Dose-Response Relationship, Drug
Dose
business.industry
Physiology
Renal function
Pharmacology
Kidney
Drug Administration Schedule
Nephrotoxicity
chemistry.chemical_compound
Infectious Diseases
chemistry
Animals
Immunology and Allergy
Medicine
Gentamicin
Trough Concentration
Rabbits
Gentamicins
business
medicine.drug
Clearance
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....3517d1887dc788e208c1486eafeda062