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Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma
- Source :
- Molecules, Vol 21, Iss 6, p 769 (2016), Molecules; Volume 21; Issue 6; Pages: 769, Molecules
- Publication Year :
- 2016
- Publisher :
- MDPI AG, 2016.
-
Abstract
- Rosmarinic acid (RA) has numerous pharmacologic effects, including anti-oxidant, anti-inflammatory, and analgesic effects. This study aimed to evaluate the preventive activity of RA in a murine model of asthma and to investigate its possible molecular mechanisms. Female BALB/c mice sensitized and challenged with ovalbumin (Ova) were pretreated with RA (5, 10 or 20 mg/kg) at 1 h before Ova challenge. The results demonstrated that RA markedly inhibited increases in inflammatory cells and Th2 cytokines in the bronchoalveolar lavage fluid (BALF), significantly reduced the total IgE and Ova-specific IgE concentrations, and greatly ameliorated airway hyperresponsiveness (AHR) compared with the control Ova-induced mice. Histological analyses showed that RA substantially decreased the number of inflammatory cells and mucus hypersecretion in the airway. In addition, our results suggested that the protective effects of RA might be mediated by the suppression of ERK, JNK and p38 phosphorylation and activation of nuclear factor-κB (NF-κB). Furthermore, RA pretreatment resulted in a noticeable reduction in AMCase, CCL11, CCR3, Ym2 and E-selectin mRNA expression in lung tissues. These findings suggest that RA may effectively delay the progression of airway inflammation.
- Subjects :
- 0301 basic medicine
CCR3
Pharmaceutical Science
Immunoglobulin E
Antioxidants
NF-κB
Analytical Chemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
RA
preventive
asthma
MAPK
mRNA expression
Lung
CCL11
Analgesics
biology
medicine.diagnostic_test
respiratory system
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
Molecular Medicine
Female
Bronchoalveolar Lavage Fluid
p38 mitogen-activated protein kinases
Depsides
Article
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
medicine
Animals
Humans
Physical and Theoretical Chemistry
Inflammation
business.industry
Organic Chemistry
Mucus
Disease Models, Animal
Ovalbumin
030104 developmental biology
Bronchoalveolar lavage
chemistry
Cinnamates
Immunology
biology.protein
business
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....351f4ce9f023dedae7d208961db7030b