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Sampling tissue volumes using frequency-domain photon migration
- Source :
- Physical Review E. 69
- Publication Year :
- 2004
- Publisher :
- American Physical Society (APS), 2004.
-
Abstract
- We demonstrate the use of Monte Carlo simulations to generate photon scattering density functions (PSDFs) that represent the tissue volume sampled by steady-state and frequency-domain photon migration. We use these results to illustrate how scaling laws can be developed to determine the mean sampling depth of the multiply scattered photons detected by photon migration methods that remain valid outside the bounds of the standard diffusion approximation, i.e., at small source-detector separations and in media where the optical absorption is significant relative to scattering. Using both the PSDF computation and the newly formulated scaling laws, we focus on a comprehensive description of the effects of source modulation frequency, optical absorption, and source-detector separation on the depth of the sampled tissue volume as well as the sensitivity of frequency-domain photon migration measurements to the presence of a localized absorption heterogeneity.
- Subjects :
- Physics
Photons
Models, Statistical
Photon
Scattering
Monte Carlo method
Biophysics
Monte Carlo method for photon transport
Biophysical Phenomena
Diffusion
Frequency domain
Photon transport in biological tissue
Scattering, Radiation
Statistical physics
Absorption (electromagnetic radiation)
Monte Carlo Method
Photon diffusion
Subjects
Details
- ISSN :
- 15502376 and 15393755
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Physical Review E
- Accession number :
- edsair.doi.dedup.....354a5ab3843f0db883cf88f98833629e