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Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 8208, p 8208 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Alzheimer’s disease (AD) is a progressive neurodegenerative disease and accounts for most cases of dementia. The prevalence of AD has increased in the current rapidly aging society and contributes to a heavy burden on families and society. Despite the profound impact of AD, current treatments are unable to achieve satisfactory therapeutic effects or stop the progression of the disease. Finding novel treatments for AD has become urgent. In this paper, we reviewed novel therapeutic approaches in five categories: anti-amyloid therapy, anti-tau therapy, anti-neuroinflammatory therapy, neuroprotective agents including N-methyl-D-aspartate (NMDA) receptor modulators, and brain stimulation. The trend of therapeutic development is shifting from a single pathological target to a more complex mechanism, such as the neuroinflammatory and neurodegenerative processes. While drug repositioning may accelerate pharmacological development, non-pharmacological interventions, especially repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), also have the potential for clinical application. In the future, it is possible for physicians to choose appropriate interventions individually on the basis of precision medicine.
- Subjects :
- 0301 basic medicine
QH301-705.5
medicine.medical_treatment
precision medicine
Anti-Inflammatory Agents
brain stimulation
Disease
Review
Neuroprotection
Catalysis
tDCS
neuroinflammation
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
rTMS
medicine
Dementia
Animals
Humans
tau
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
Transcranial direct-current stimulation
Mechanism (biology)
business.industry
Organic Chemistry
amyloid
General Medicine
Precision medicine
medicine.disease
Transcranial Magnetic Stimulation
Computer Science Applications
Drug repositioning
Chemistry
030104 developmental biology
Neuroprotective Agents
NMDA
Brain stimulation
neuroprotection
business
Neuroscience
Alzheimer’s disease
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....354a7de9f42e7cd6a9cf86fda0a3fb29