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Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Source :
- Journal of Alzheimer's disease : JAD. 61(3)
- Publication Year :
- 2018
-
Abstract
- The purpose of our article is to assess the current understanding of Indian spice ‘Curcumin’ against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural products, such as ginger, curcumin and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, anti-oxidant, anti-arthritis, pro-healing and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on amyloid-β and curcumin has revealed that curcumin prevents amyloid-β aggregation and crosses the blood brain barrier (BBB), reach brain cells and protect neurons from various toxic insults of aging and amyloid-β in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin’s bioavailability and urgent need for new formulation to increase its brain levels to treat patients with AD.
- Subjects :
- 0301 basic medicine
Antioxidant
Curcumin
medicine.medical_treatment
Disease
Pharmacology
medicine.disease_cause
Article
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Alzheimer Disease
Diabetes mellitus
medicine
Animals
Humans
Cognitive decline
Spices
Randomized Controlled Trials as Topic
Amyloid beta-Peptides
business.industry
General Neuroscience
General Medicine
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Disease Models, Animal
030104 developmental biology
Neuroprotective Agents
chemistry
Blood-Brain Barrier
Toxicity
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 61
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....354b8247a885ca84eb3e4f08d9fce9e8