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Motor cortex plasticity response to acute cardiorespiratory exercise and intermittent theta-burst stimulation is attenuated in premanifest and early Huntington’s disease
- Source :
- Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022), Scientific Reports
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Huntington’s disease (HD) mouse models suggest that cardiovascular exercise may enhance neuroplasticity and delay disease signs, however, the effects of exercise on neuroplasticity in people with HD are unknown. Using a repeated-measures experimental design, we compared the effects of a single bout of high-intensity exercise, moderate-intensity exercise, or rest, on motor cortex synaptic plasticity in 14 HD CAG-expanded participants (9 premanifest & 5 early manifest) and 20 CAG-healthy control participants, using transcranial magnetic stimulation. Measures of cortico-motor excitability, short-interval intracortical inhibition and intracortical facilitation were obtained before and after a 20-minute bout of either high-intensity interval exercise, moderate-intensity continuous exercise, or rest, and again after intermittent theta burst stimulation (iTBS). HD participants showed less inhibition at baseline compared to controls. Whereas the control group showed increased excitability and facilitation following high-intensity exercise and iTBS, the HD group showed no differences in neuroplasticity responses following either exercise intensity or rest, with follow-up Bayesian analyses providing consistent evidence that these effects were absent in the HD group. These findings indicate that exercise-induced synaptic plasticity mechanisms in response to acute exercise may be attenuated in HD, and demonstrate the need for future research to further investigate exercise and plasticity mechanisms in people with HD.
- Subjects :
- Adult
Male
Science
Stimulation
Plasticity
Article
Huntington's disease
medicine
Animals
Humans
Theta Rhythm
Exercise
Aged
Multidisciplinary
Neuronal Plasticity
Electromyography
business.industry
Motor Cortex
Cardiorespiratory fitness
Middle Aged
Evoked Potentials, Motor
medicine.disease
Transcranial Magnetic Stimulation
Exercise Therapy
Theta burst
Huntington Disease
medicine.anatomical_structure
Neurology
Cardiorespiratory Fitness
Medicine
Female
business
Neuroscience
Motor cortex
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....355bf7a03613674ea7e8cb01190e99da