Back to Search
Start Over
Intracranial arteriosclerosis is related to cerebral small vessel disease: a prospective cohort study
- Source :
- Neurobiology of Aging, 105, 16-24. Elsevier Inc., Vinke, E J, Yilmaz, P, van der Toorn, J E, Fakhry, R, Frenzen, K, Dubost, F, Licher, S, de Bruijne, M, Kavousi, M, Ikram, M A, Vernooij, M W & Bos, D 2021, ' Intracranial arteriosclerosis is related to cerebral small vessel disease : a prospective cohort study ', Neurobiology of Aging, vol. 105, pp. 16-24 . https://doi.org/10.1016/j.neurobiolaging.2021.04.005
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Intracranial arteriosclerosis has been increasingly recognized as a risk factor for cognitive impairment and even dementia. A possible mechanism linking intracranial arteriosclerosis to cognitive impairment and dementia involves structural brain changes including cerebral small vessel disease (CSVD). To assess whether intracranial carotid artery calcification (ICAC) and vertebrobasilar artery calcification (VBAC), as proxies for intracranial arteriosclerosis, are related to CSVD. Within the population-based Rotterdam Study, between 2003 and 2006 a computed tomography (CT)-based measurement of ICAC and VBAC and at least one magnetic resonance imaging (MRI) measurement of structural brain changes were performed from 2005 onwards in 1,489 participants. To estimate the burden of calcification independent of age, we computed age-adjusted percentile curves for ICAC and VBAC separately, based on the calcification volumes. Using the longitudinal MRI data, we assessed whether a larger calcification burden accelerates structural brain changes using appropriate statistical models for repeated outcome measures. A larger burden of ICAC and VBAC was associated with an increase of CSVD markers accelerating over time. A larger burden of ICAC and VBAC was not significantly (p > 0.05) associated with accelerated brain atrophy. Arteriosclerosis is related to accelerating structural brain changes over time.
- Subjects :
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Population
03 medical and health sciences
Rotterdam Study
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Dementia
Cognitive Dysfunction
Prospective Studies
Risk factor
Prospective cohort study
education
Aged
education.field_of_study
medicine.diagnostic_test
business.industry
General Neuroscience
Brain
Calcinosis
Magnetic resonance imaging
Arteriosclerosis
Middle Aged
Intracranial Arteriosclerosis
medicine.disease
Magnetic Resonance Imaging
Carotid Arteries
030104 developmental biology
Basilar Artery
Cerebral Small Vessel Diseases
Cardiology
Female
Neurology (clinical)
Atrophy
Geriatrics and Gerontology
Tomography, X-Ray Computed
business
030217 neurology & neurosurgery
Developmental Biology
Calcification
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....3563865e62edc18a034b805db968b617