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Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis
- Source :
- Antimicrobial Agents and Chemotherapy. 51:3445-3448
- Publication Year :
- 2007
- Publisher :
- American Society for Microbiology, 2007.
-
Abstract
- We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O -acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.
- Subjects :
- Staphylococcus aureus
Micrococcaceae
medicine.drug_class
Antibiotics
Bacteremia
medicine.disease_cause
Microbiology
Bacterial Proteins
Daptomycin
Mechanisms of Resistance
Cell Wall
Drug Resistance, Bacterial
medicine
Humans
Endocarditis
Pharmacology (medical)
Antibacterial agent
Pharmacology
biology
Acetylation
Vancomycin Resistance
Endocarditis, Bacterial
biochemical phenomena, metabolism, and nutrition
Staphylococcal Infections
bacterial infections and mycoses
Aminoacyltransferases
biology.organism_classification
medicine.disease
Anti-Bacterial Agents
Electrophoresis, Gel, Pulsed-Field
Phenotype
Infectious Diseases
Muramic Acids
Mutation
Vancomycin
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....357ca5cb1e2874009346f296aa258fa8