SCP-7, a germacrane-type sesquiterpene lactone derivative, induces ROS-mediated apoptosis in NSCLC cells in vitro and in vivo

Authors :: Yang-Yang, Zhang
Hui, Ren
Qiu-Lin, Yan
Ya-Ling, Li
Qingbo, Liu
Guo-Dong, Yao
Shao-Jiang, Song
Source :: European Journal of Pharmacology. 925:174989
Publication Year :: 2022
Publisher :: Elsevier BV, 2022.
Abstract: Scabertopin (SCP), an abundant germacrane-type sesquiterpene lactone (SLC) isolated from Elephantopus scaber, was selected as a reference compound for modification and evaluation as anticancer agents for non-small cell lung cancer (NSCLC) treatment. All derivatives (SCP-1-SCP-13) except for SCP-3 showed potential inhibitory effect (IC

Subjects :: Molecular Docking Simulation
Pharmacology
Lactones
Sesquiterpenes, Germacrane
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Phytochemicals
Humans
Antineoplastic Agents
Apoptosis
Reactive Oxygen Species

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