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Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery
- Source :
- PloS one, vol 8, iss 4, PLoS ONE, PLoS ONE, Vol 8, Iss 4, p e60164 (2013), Miaskowski, C; Dodd, M; Paul, SM; West, C; Hamolsky, D; Abrams, G; et al.(2013). Lymphatic and Angiogenic Candidate Genes Predict the Development of Secondary Lymphedema following Breast Cancer Surgery. PLoS ONE, 8(4). doi: 10.1371/journal.pone.0060164. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4wf6856w
- Publication Year :
- 2013
- Publisher :
- eScholarship, University of California, 2013.
-
Abstract
- The purposes of this study were to evaluate for differences in phenotypic and genotypic characteristics in women who did and did not develop lymphedema (LE) following breast cancer treatment. Breast cancer patients completed a number of self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping was done using a custom genotyping array. No differences were found between patients with (n = 155) and without LE (n = 387) for the majority of the demographic and clinical characteristics. Patients with LE had a significantly higher body mass index, more advanced disease and a higher number of lymph nodes removed. Genetic associations were identified for four genes (i.e., lymphocyte cytosolic protein 2 (rs315721), neuropilin-2 (rs849530), protein tyrosine kinase (rs158689), vascular cell adhesion molecule 1 (rs3176861)) and three haplotypes (i.e., Forkhead box protein C2 (haplotype A03), neuropilin-2 (haplotype F03), vascular endothelial growth factor-C (haplotype B03)) involved in lymphangiogensis and angiogenesis. These genetic associations suggest a role for a number of lymphatic and angiogenic genes in the development of LE following breast cancer treatment. © 2013 Miaskowski et al.
- Subjects :
- Candidate gene
Angiogenesis
Vascular Endothelial Growth Factor C
lcsh:Medicine
Body Mass Index
0302 clinical medicine
Breast Tumors
2.1 Biological and endogenous factors
Medicine
Lymphedema
Aetiology
lcsh:Science
Cancer
2. Zero hunger
0303 health sciences
Multidisciplinary
Palliative Care
Single Nucleotide
Middle Aged
Protein-Tyrosine Kinases
3. Good health
Lymphatic system
Oncology
030220 oncology & carcinogenesis
Female
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Secondary lymphedema
General Science & Technology
Vascular Cell Adhesion Molecule-1
Breast Neoplasms
Polymorphism, Single Nucleotide
03 medical and health sciences
Nursing Science
Breast cancer
Breast Cancer
Genetics
Humans
Genetic Predisposition to Disease
Polymorphism
Genotyping
030304 developmental biology
Aged
Clinical Genetics
business.industry
lcsh:R
Haplotype
Cancers and Neoplasms
medicine.disease
Surgery
Neuropilin-2
Cross-Sectional Studies
Haplotypes
lcsh:Q
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- PloS one, vol 8, iss 4, PLoS ONE, PLoS ONE, Vol 8, Iss 4, p e60164 (2013), Miaskowski, C; Dodd, M; Paul, SM; West, C; Hamolsky, D; Abrams, G; et al.(2013). Lymphatic and Angiogenic Candidate Genes Predict the Development of Secondary Lymphedema following Breast Cancer Surgery. PLoS ONE, 8(4). doi: 10.1371/journal.pone.0060164. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4wf6856w
- Accession number :
- edsair.doi.dedup.....35acc1e39b44ad6458511b34242f6d2f