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Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest
- Source :
- Grand, J, Kjaergaard, J, Nielsen, N, Friberg, H, Cronberg, T, Bro-Jeppesen, J, Karsdal, M A, Nielsen, H B, Frydland, M, Henriksen, K, Mattsson, N, Zetterberg, H & Hassager, C 2019, ' Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest ', Biomarkers, vol. 24, no. 6, pp. 584-591 . https://doi.org/10.1080/1354750X.2019.1609580
- Publication Year :
- 2019
-
Abstract
- Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Results: Median (quartile 1 - quartile 3) tau-A (ng/ml) values were 58 (43-71) versus 51 (43-67), 72 (57-84) versus 71 (59-82) and 76 (61-92) versus 75 (64-89) for good versus unfavourable outcome at 24, 48 and 72 h, respectively (pgroup = 0.95). Median tau C (ng/ml) values were 38 (29-50) versus 36 (29-49), 49 (38-58) versus 48 (33-59) and 48 (39-59) versus 48 (36-62) (pgroup = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 h; tau-A: 0.51 and tau-C: 0.51). Conclusions: Serum levels of tau fragments were unable to predict neurological outcome after OHCA.
- Subjects :
- Male
medicine.medical_specialty
Resuscitation
Neurology
tau Proteins/blood
Health, Toxicology and Mutagenesis
Clinical Biochemistry
Hypoxia, Brain/blood
tau Proteins
030204 cardiovascular system & hematology
Biochemistry
Out of hospital cardiac arrest
Body Temperature
03 medical and health sciences
0302 clinical medicine
Serum biomarkers
medicine
Humans
Prospective Studies
Hypoxia, Brain
Anoxic brain injury
Cause of death
Aged
business.industry
Out-of-Hospital Cardiac Arrest/blood
Middle Aged
Prognosis
Survival Analysis
Cardiopulmonary Resuscitation
Peptide Fragments
Treatment Outcome
ROC Curve
030220 oncology & carcinogenesis
Emergency medicine
Female
Cardiopulmonary Resuscitation/methods
business
Peptide Fragments/blood
Biomarkers
Out-of-Hospital Cardiac Arrest
Biomarkers/blood
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Grand, J, Kjaergaard, J, Nielsen, N, Friberg, H, Cronberg, T, Bro-Jeppesen, J, Karsdal, M A, Nielsen, H B, Frydland, M, Henriksen, K, Mattsson, N, Zetterberg, H & Hassager, C 2019, ' Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest ', Biomarkers, vol. 24, no. 6, pp. 584-591 . https://doi.org/10.1080/1354750X.2019.1609580
- Accession number :
- edsair.doi.dedup.....35aea16a818829798a32f9c73305fffe
- Full Text :
- https://doi.org/10.1080/1354750X.2019.1609580