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A pair of novel bisindole alkaloid enantiomers from marine fungus Fusarium sp. XBB-9
- Source :
- Natural Product Research. 35:1497-1503
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- A preliminary research on the marine fungus Fusarium sp. XBB-9 resulted in a pair of novel bisindole alkaloid enantiomers, (+)- and (–)-fusaspoid A (1a/1b) and 12 diverse compounds. One strain many compound (OSMAC) method was used to enhance as many biosynthetic pathways as possible. The structures of the compounds were elucidated by spectroscopic analysis, and the absolute configuration of 1a was determined by X-ray single-crystal diffraction analysis. Compounds 1a and 1b were tested for cytotoxic activity against HCT-15, RKO cell lines, but were inactive. Compounds 1a and 1b were the first example of bisindole alkaloids isolated from fungus Fusarium sp. XBB-9.
- Subjects :
- Fusarium
biology
Strain (chemistry)
010405 organic chemistry
Chemistry
Stereochemistry
Alkaloid
Organic Chemistry
Absolute configuration
Plant Science
Fungus
biology.organism_classification
01 natural sciences
Biochemistry
0104 chemical sciences
Analytical Chemistry
010404 medicinal & biomolecular chemistry
Cell culture
Enantiomer
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi.dedup.....35b0ca7f5299aec8915fac76190e36e7