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Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
- Source :
- Cell. (2):331-340
-
Abstract
- RelB, a member of the NF-kappa B/Rel family of transcription factors, has been implicated in the constitutive expression of kappa B-regulated genes in lymphoid tissues. We have generated mice carrying a germline mutation of the relB gene, resulting in the absence of RelB protein and a dramatic reduction of constitutive kappa B-binding activity in thymus and spleen. Mice homozygous for the disrupted relB locus had phenotypic abnormalities including multifocal, mixed inflammatory cell infiltration in several organs, myeloid hyperplasia, splenomegaly due to extramedullary hematopoiesis, and a reduced population of thymic dendritic cells. RelB-deficient animals also had an impaired cellular immunity, as observed in contact sensitivity experiments. Thus, RelB plays a decisive role in the hematopoietic system, and its absence cannot be functionally compensated by any other member of the NF-kappa B/Rel family.
- Subjects :
- Male
Cellular immunity
Aging
Population
Transcription Factor RelB
Mice, Transgenic
Biology
Transfection
General Biochemistry, Genetics and Molecular Biology
Mice
Germline mutation
Bone Marrow
Proto-Oncogene Proteins
Animals
education
Lung
Inflammation
education.field_of_study
Immunity, Cellular
Mice, Inbred ICR
Biochemistry, Genetics and Molecular Biology(all)
RELB
Stem Cells
NF-kappa B
Exons
NFKB1
Flow Cytometry
Introns
Mice, Mutant Strains
Hematopoiesis
Mice, Inbred C57BL
Haematopoiesis
Blastocyst
Liver
Cancer research
Female
Lymph Nodes
Proto-Oncogene Proteins c-rel
Spleen
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....35b23107977203dc02d14b13355d1f34
- Full Text :
- https://doi.org/10.1016/0092-8674(95)90416-6