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Population pharmacokinetics of intravenous amoxicillin in very low birth weight infants
- Source :
- Journal of pharmaceutical sciences. 86(11)
- Publication Year :
- 1997
-
Abstract
- The population pharmacokinetics of amoxicillin were determined in 40 very premature infants (or = 32 week gestational age,1500 g birth weight) who were receiving intravenous amoxicillin (50 mg/ kg, every 12 h) during the first days after birth. Serum amoxicillin concentrations were measured by HPLC. Clearance (CL) and volume of distribution (Vd) were modeled alone and under the influence of demographic and clinical covariates with a 1-compartment model with first-order elimination. The final population models with influential covariates were: CL(L/h) = 0.0000610 x body weight (g) and CL (L/h) = 0.0000805 x body weight (g), for infants also receiving gentamicin and not receiving gentamicin, respectively; Vd(L) = 0.678. The interpatient standard deviation (SD) for CL was 0.0351 L/h, and for Vd was 0.365 L. The intrapatient variability (SD) among observed and model-predicted serum concentrations was 13.7 mg/L. Evaluation of the predictive performance of this model in another group of infants (n = 16) indicated statistically insignificant bias (p0.05) of 3 mg/L among pairs of observed and Bayesian-predicted amoxicillin concentrations. The average population CL was smaller, but the average Vd and terminal half-life (t1/2) were larger than previously reported for healthy adults.
- Subjects :
- Male
Metabolic Clearance Rate
Population
Pharmaceutical Science
Physiology
Penicillins
Pharmacokinetics
Blood plasma
medicine
Humans
Infant, Very Low Birth Weight
education
Antibacterial agent
education.field_of_study
business.industry
Infant, Newborn
Gestational age
Amoxicillin
Drug interaction
Low birth weight
Anesthesia
Injections, Intravenous
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 86
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of pharmaceutical sciences
- Accession number :
- edsair.doi.dedup.....35b37585179070d1eebec752ef49c0ca