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Fendosal (HP 129): A potent anti-inflammatory and analgesic compound
- Source :
- Agents and Actions. 8:209-217
- Publication Year :
- 1978
- Publisher :
- Springer Science and Business Media LLC, 1978.
-
Abstract
- Fendosal (HP 129) is one of a series of potent non-steroidal anti-inflammatory agents. Fendosal was compared with aspirin in several anti-inflammatory and analgesic bioassay procedures. Results indicate that fendosal has an anti-inflammatory activity 1.4 times greater than does aspirin in carrageenan-induced rat paw edema. Fendosal is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation. The analgesic activity of fendosal is considered to be superior to that of aspirin, with the advantage of a prolonged duration of action. The gastric-irritating properties of fendosal are very low in comparison with those of aspirin. Fendosal has a much wider separation of effective and gastric-irritating doses than does aspirin.
- Subjects :
- Allergy
Indoles
medicine.drug_class
Immunology
Analgesic
Inflammation
Pharmacology
Toxicology
Anti-inflammatory
Edema
Hydroxybenzoates
medicine
Animals
Bioassay
Pharmacology (medical)
Aspirin
Granuloma
business.industry
Anti-Inflammatory Agents, Non-Steroidal
medicine.disease
Arthritis, Experimental
Salicylates
Rats
Female
Polyarthritis
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 1420908X and 00654299
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Agents and Actions
- Accession number :
- edsair.doi.dedup.....35d998a5c7a8f425742ef82db21fed6b