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Identification of four new DR52-associated DRB1 alleles: DRB1*1424, *1425, *1323 and *1324
- Source :
- Tissue antigens. 50(1)
- Publication Year :
- 1997
-
Abstract
- Four previously unreported DR52-associated DRB1 alleles have been characterized through DNA sequencing, contributing to the diversity of the HLA system. DRB1*1424 is nearly identical to DRB1*1402 in the second exon, except that it contains the "I---A" motif found at codons 67-71 common to the DRB1*15 alleles. DRB1*1425 contains the "A--H" motif, found in DRB1*1401 at codons 57-60, in a sequence otherwise identical with the second exon of DRB1*1307. Compared with DRB1*11012, DRB1*1323 contains three predicted amino acid changes at codons 58 (ala-->glu), 67 (phe-->ile), and 71 (arg-->glu). The sequence of DRB1*1324 is identical to exon 2 of DRB1*1103, except that DRB1*1324 does not contain the GAG at codon 58 characteristic of the DRB1*11 alleles. These new alleles may have arisen through gene conversion, and they contribute to the complexity of the DR6 family.
- Subjects :
- musculoskeletal diseases
Immunology
Molecular Sequence Data
Human leukocyte antigen
Biology
Biochemistry
DNA sequencing
Exon
immune system diseases
Genetics
Immunology and Allergy
Humans
Gene conversion
Allele
skin and connective tissue diseases
Alleles
chemistry.chemical_classification
Polymorphism, Genetic
Base Sequence
General Medicine
DNA
HLA-DR Antigens
Molecular biology
Amino acid
chemistry
HLA-DRB1 Chains
Subjects
Details
- ISSN :
- 00012815
- Volume :
- 50
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Tissue antigens
- Accession number :
- edsair.doi.dedup.....35e051c02cc57ff4d0c18d81a3e8accd