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Molecular Characterization and Clinical Treatment of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Patients With TP53 Mutation
- Source :
- Clinical Lymphoma Myeloma and Leukemia. 21:841-851
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Mutations in TP53 in myeloid neoplasms patients have been associated with poor prognosis. Effective treatments to these patients remain unclear. Patients and Methods In this study, we retrospectively analyzed diagnostic and outcomes of 31 Acute Myeloid leukemia (AML) and 9 Myelodysplastic syndromes (MDS) patients with TP53 mutation at our hospital from September 2015 to October 2020. Results A total of 42 variants (28 unique variants) in the coding region of TP53 gene were identified, and most were missense mutation (34 of 42, 81%). The median overall survival (OS) was 8 months for the AML patients (1-32 months) and 7 months for the MDS patients (3-27 months). There were 35 and 13 patients underwent frontline chemical therapy and Allo-HSCT, respectively. The overall response rate was 45.3% (16/35) for the frontline treatment. There was no significant difference between intensive and low-intensity regimens on either response to the frontline treatment (P = .255) or overall survival (P = .078). Patients, who achieved complete or partial remission at the frontline treatment, presented a higher survival than patients in non–remission, no matter transplant or not. Conclusion This study corroborates that improving the response to the first-line treatment could prolong the survival of myeloid neoplasms patients with TP53 mutation. Allo-HSCT could be a curative option for patients with TP53 mutation, when in complete remission during the first-line treatment.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Myeloid
Tp53 mutation
hemic and lymphatic diseases
Internal medicine
medicine
Overall survival
Humans
Missense mutation
Clinical treatment
Retrospective Studies
business.industry
Myelodysplastic syndromes
Complete remission
Myeloid leukemia
Hematology
medicine.disease
Leukemia, Myeloid, Acute
medicine.anatomical_structure
Myelodysplastic Syndromes
Mutation
Tumor Suppressor Protein p53
business
Subjects
Details
- ISSN :
- 21522650
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Clinical Lymphoma Myeloma and Leukemia
- Accession number :
- edsair.doi.dedup.....35ec5d10ff45bee84282700659770d92