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Vaccination and antigenic drift in influenza
- Source :
- Vaccine. 26
- Publication Year :
- 2008
-
Abstract
- The relationship between influenza antigenic drift and vaccination lies at the intersection of evolutionary biology and public health, and it must be viewed and analyzed in both contexts simultaneously. In this paper, I review what is known about the effects of antigenic drift on vaccination and the effects of vaccination on antigenic drift, and I suggest some simple ways to detect the presence of antigenic drift in seasonal influenza data. If antigenic drift occurs on the time scale of a single influenza season, it may be associated with the presence of herd immunity at the beginning of the season and may indicate a need to monitor for vaccine updates at the end of the season. The relationship between antigenic drift and vaccination must also be viewed in the context of the global circulation of influenza strains and the seeding of local and regional epidemics. In the data sets I consider — from New Zealand, New York, and France — antigenic drift can be statistically detected during some seasons, and seeding of epidemics appears to be endogenous sometimes and exogenous at other times. Improved detection of short-term antigenic drift and epidemic seeding would significantly benefit influenza monitoring efforts and vaccine selection.
- Subjects :
- Virulence
General Veterinary
General Immunology and Microbiology
Influenza A Virus, H3N2 Subtype
Genetic Drift
Vaccination
Public Health, Environmental and Occupational Health
Influenza season
Context (language use)
Biology
Antigenic Variation
Biological Evolution
Virology
Article
Antigenic drift
Herd immunity
Seasonal influenza
Influenza A Virus, H1N1 Subtype
Infectious Diseases
Influenza Vaccines
Influenza, Human
Humans
Molecular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....35f1beb9898159078e2ce719e97e547c