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Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure

Authors :
Versporten, Ann
Gyssens, Inge C
Pulcini, Céline
Monnier, Annelie A
Schouten, Jeroen
Milanič, Romina
Stanić Benić, Mirjana
Tebano, Gianpiero
Le Maréchal, Marion
Zanichelli, Veronica
Huttner, Benedikt
Vlahović-Palčevski, Vera
Goossens, Herman
Hulscher, Marlies E
Adriaenssens, Niels
Beović, Bojana
Bavestrello, Luis
Cohen, Jon
Cortoos, Pieter-Jan
Dhillon, Harpal
Drew, Richard
Fernandes, Prabhavathi
Findlay, David
Friedland, Ian
Gould, Ian
Hicks, Lauri
Longshaw, Christopher
Llor, Carl
McGeer, Allison
Okeke, Iruka N
Plachouras, Diamantis
Poulakou, Garyfallia
Rex, John H
Tängdén, Thomas
Saust, Laura Trolle
Richon, Claudine
Roblot, France
Stichele, Robert vander
Verweij, Marcel
Wertheim, Heiman
the DRIVE-AB WP1 group
APH - Aging & Later Life
University of Antwerp (UA)
Radboud University Medical Center [Nijmegen]
Hasselt University (UHasselt)
Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC)
Université de Lorraine (UL)
Service des Maladies Infectieuses et Tropicales [CHRU Nancy]
Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
University of Rijeka
Geneva University Hospitals and Geneva University
DRIVE AB
DRIVE-AB WP1 Grp
Source :
Journal of Antimicrobial Chemotherapy, 73(suppl_6), vi59-vi66. Oxford University Press, Journal of Antimicrobial Chemotherapy, Vol. 73, No suppl_6 (2018) pp. vi59-vi66, Journal of Antimicrobial Chemotherapy, Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2018, 73 (suppl_6), pp.vi59-vi66. ⟨10.1093/jac/dky119⟩, Journal of Antimicrobial Chemotherapy, 73, vi59-vi66, Journal of Antimicrobial Chemotherapy, 73, suppl_6, pp. vi59-vi66, The journal of antimicrobial chemotherapy, Volume 73, Issue suppl_6
Publication Year :
2018

Abstract

Contains fulltext : 193592.pdf (Publisher’s version ) (Open Access) Background: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. Objectives: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter)national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use.

Details

Language :
English
ISSN :
03057453 and 14602091
Database :
OpenAIRE
Journal :
Journal of Antimicrobial Chemotherapy, 73(suppl_6), vi59-vi66. Oxford University Press, Journal of Antimicrobial Chemotherapy, Vol. 73, No suppl_6 (2018) pp. vi59-vi66, Journal of Antimicrobial Chemotherapy, Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2018, 73 (suppl_6), pp.vi59-vi66. ⟨10.1093/jac/dky119⟩, Journal of Antimicrobial Chemotherapy, 73, vi59-vi66, Journal of Antimicrobial Chemotherapy, 73, suppl_6, pp. vi59-vi66, The journal of antimicrobial chemotherapy, Volume 73, Issue suppl_6
Accession number :
edsair.doi.dedup.....35f3cc6a7dc2afb381d4d0e71f3ee35b