Back to Search
Start Over
Left ventricular mass and progenitor cells in chronic heart failure patients
- Source :
- Internal and Emergency Medicine. 10:329-335
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The aim of the study was to evaluate the association between circulating (CPCs) and endothelial (EPCs) progenitor cells and left ventricular (LV) remodeling in chronic heart failure (HF). 85 HF patients, ranging 29–89 years, 83.5 % males, 45.9 % ischemic, NYHA functional class II–IV, with a LV ejection fraction ≤40 % were studied. LV ejection fraction, LV end-diastolic and end-systolic (LVESV) volumes, LV mass and tricuspid annular plane systolic excursion (TAPSE) were evaluated, and, when indicated, indexed for body surface area (BSA). CPCs and EPCs number was assessed using flow cytometry. CPCs were defined as CD34+, CD133+ and CD34+/CD133+. EPCs, identified through their expression of KDR, were defined as CD34+/KDR+, CD133+/KDR+ and CD34+/CD133+/KDR+. All EPCs were negatively related to LVESV/BSA (r = −0.24, p = 0.02 for all EPC’s populations), and to LVmass/BSA (CD34+KDR+; r = −0.30, p = 0.005; CD133+KDR+; r = −0.31, p = 0.004; CD34+CD133+KDR+; r = −0.29, p = 0.007). No differences in EPCs levels in relation to cardiovascular risk factors, medications, etiology, age or gender were observed. CPCs number was higher in women, and lower in ischemic patients. In logistic regression analyses, the low EPCs’ number was associated with an increased likelihood of abnormal LVmass/BSA. CPCs proved to be higher and EPCs lower in patients with severely abnormal LVmass/BSA (gr/m2, ≥122 in women and ≥149 in men). Our results suggest a correlation between LV remodeling and progenitor cells. This is noteworthy considering that it has been suggested that bone marrow-derived EPCs participate in cardiac regeneration and function recovery in the setting of progressive HF.
- Subjects :
- Adult
Male
medicine.medical_specialty
Heart Ventricles
CD34
Flow cytometry
Left ventricular mass
Internal medicine
Internal Medicine
medicine
Humans
Progenitor cell
Ventricular remodeling
neoplasms
Aged
Aged, 80 and over
Heart Failure
Body surface area
Ejection fraction
Ventricular Remodeling
medicine.diagnostic_test
business.industry
Stem Cells
Middle Aged
Flow Cytometry
medicine.disease
Endocrinology
Heart failure
embryonic structures
cardiovascular system
Emergency Medicine
Cardiology
Female
Endothelium, Vascular
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 19709366 and 18280447
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Internal and Emergency Medicine
- Accession number :
- edsair.doi.dedup.....361098adeea972d9ebf6e01f5181464c