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Hyperinsulinemia restrains endometrial angiogenesis during decidualization in early pregnancy
- Source :
- Journal of Endocrinology. 243:137-148
- Publication Year :
- 2019
- Publisher :
- Bioscientifica, 2019.
-
Abstract
- Previous research on the role of insulin has focused on metabolism. This study investigated the effect of insulin on angiogenesis in endometrial decidualization. High insulin-treated mouse model was constructed by subcutaneous injection of insulin. Venous blood glucose, serum insulin, P4, E2, FSH and LH levels in the pregnant mice were detected by ELISA. Decidual markers, angiogenesis factors and decidual vascular network were detected during decidualization in the pregnant mouse model and an artificially induced decidualization mouse model. Tube formation ability and angiogenesis factors expression were also detected in high insulin-treated HUVECS cells. To confirm whether autophagy participates in hyperinsulinemia-impaired decidual angiogenesis, autophagy was detected in vivo and in vitro. During decidualization, in the condition of high insulin, serum insulin and blood glucose were significantly higher, while ovarian steroid hormones were also disordered (P P in vivo and in vitro (P P P
- Subjects :
- Blood Glucose
Vascular Endothelial Growth Factor A
0301 basic medicine
medicine.medical_specialty
Angiogenesis
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Endometrium
Mice
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pregnancy
Hyperinsulinism
Internal medicine
Autophagy
Decidua
Human Umbilical Vein Endothelial Cells
Hyperinsulinemia
Animals
Humans
Hypoglycemic Agents
Insulin
Medicine
Tube formation
business.industry
Decidualization
medicine.disease
Hormones
Vascular endothelial growth factor A
030104 developmental biology
Blood Vessels
Female
business
Hormone
Subjects
Details
- ISSN :
- 14796805 and 00220795
- Volume :
- 243
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....36194db527bfce47bd8f3e00b789df9b